of malignant pleural mesothelioma (MPM) is the most common type of mesothelioma with a history of exposure to asbestos is the major risk factor. Although the search for new therapies that target genes and processes driving MPM is slow , two new approaches, which are immediately available to you, have shown significant improvements in the standard treatment in clinical trials.
Before we discuss these improved treatment options, we must first briefly examine two key aspects of MPM progression. Angiogenesis and epigenetic Regulation
angiogenesis
You've probably heard of angiogenesis. It is a physiological process that tumors use to recruit new blood vessels to sustain their continued growth. They do so by manipulating the expression of genes that promote and direct the development of new, leaky blood vessels from existing. This new supply of blood not only allows the tumor to grow, but also provides a mechanism for tumor cells to metastasize (travel through the P body ).
the process of angiogenesis is regulated by its own unique combination of genes, separate from those involved in the normal formation of new blood vessels (a process known as vasculogenesis). That is, it turns out, gives us the opportunity for successful treatment by targeting these unique gene combinations.
One of the most specific and critical regulators of angiogenesis is a family of vascular endothelial growth factors (VEGFs), which regulate endothelial cell proliferation (formation of new blood vessels), vascular permeability, and survival.In MPM, more an expression of VEGF is common and correlate with lower rates and reduce the total forgiveness of patient survival. Clearly, the effective targeting of VEGFs result in restricting blood flow to the tumor so successfully prohibit their growth. And that is exactly what we've seen in current clinical trials. (More on that in a bit .)
epigenetic Regulation:
a significant development in the treatment of MPM include studies that focus on the manipulation of gene regulation process, commonly referred to as epigenetic regulation. In MPM, tumor suppressor genes (genes that, when functioning properly, of course, prohibit the growth of tumor cells) were silenced because of three key forms of epigenetic regulation
1 Removal of acetyl groups by Histone deacetylases (HDACs );
2 Inhibition of Histone acetyltransferases (caps), which add acetyl groups, and
3 Addition of methyl groups of DNA methyltransferases (DNMTs ).
In MPM, too much expression of HDACs, together with the inhibition of caps is considered a key process that leads to progression bolesti.Pretjerano DNMTs expression occurs in most cancers.
benefits of targeting epigenetic processes that are reversible. In contrast to the mutated gene that can not be reactivated, it is possible to reactivate tumor suppressor genes are silenced by epigenetic processes. Thus, effective treatment must include a process by which tumor suppressor genes are supported to maintain their functions and to activate when the already silenced.
In this sense, there are numerous clinical trials are currently investigating the use of unique combinations of drugs to prevent the silencing of tumor suppressor genes, and to stop the flow of blood to tumors. current clinical trials using HDAC and VEGF inhibitors show significant advantages in patient survival. For example, Vorinostat, an inhibitor of HDACs, has recently been shown to be useful for advanced mesothelioma patients whose cancer progressed after standard chemotherapy.
the continued development and introduction of these new drugs as part of standard treatment will undoubtedly be realized in the next few years. In the meantime, there are some very simple and effective natural measures you can take immediately that will directly and strongly affect the growth of cancer.
Although clinical trials provide the basis for current molecular-targeted therapy, plant phytochemicals (also known as: Nutraceuticals). Provide exciting opportunities as an aid gene regulation
Science has identified the following as nutraceuticals that a significant effect in slowing the mechanisms involved in the progression of MPM. It is therefore imperative, as part of their treatment protocol, to ensure that these substances are part of your daily diet in appropriate combinations.
The next part is a list of nutraceuticals that have shown to directly affect the epigenetic regulation and angiogenisis in various cancers.
To prevent DNMTs to maintain the tumor suppressor gene function, we need to consume foods as follows:
apigenin (parsley, thyme), curcumin (turmeric, ginger, mustard), EGCG (green tea, nutmeg)
genistein (soy), resveratrol (red wine, grapes Skins), Sulforaphane (broccoli, Brussels sprouts, cabbage)
To prevent HDACs to maintain the tumor suppressor gene function, we need to consume these foods:
allyl mercaptan <>( Garlic), curcumin (turmeric, ginger, mustard), genistein (soy) Sulforaphane (broccoli, Brussels sprouts, cabbage)
to activate the caps to activate tumor suppressors, we regularly have to consume these foods:
curcumin (turmeric, ginger, mustard) EGCG (green tea, nutmeg), genistein (soy)
In order to prevent the VEGFs to prevent further angiogenesis, we must ensure that these substances are part of our daily diet:
curcumin (turmeric, ginger, mustard), EGCG (green tea, nutmeg), 6-Gingerol (Ginger)
Conclusion:
There are many molecular pathways and genes involved in MPM. Above we have explored only a few. However, including a daily diet of Nutraceuticals above will go a long way to improve their statistical chances of remission and prevention of disease, as these nutraceuticals are revealing themselves to be important in the treatment and prevention of many cancers.
There are many molecular pathways and genes involved in MPM. Above we have explored only a few. However, including a daily diet of Nutraceuticals above will go a long way to improve their statistical chances of remission and prevention of disease, as these nutraceuticals are revealing themselves to be important in the treatment and prevention of many cancers.
...There are many molecular pathways and genes involved in MPM. Above we have explored only a few. However, including a daily diet of Nutraceuticals above will go a long way to improve their statistical chances of remission and prevention of disease, as these nutraceuticals are revealing themselves to be important in the treatment and prevention of many cancers.
...There are many molecular pathways and genes involved in MPM. Above we have explored only a few. However, including a daily diet of Nutraceuticals above will go a long way to improve their statistical chances of remission and prevention of disease, as these nutraceuticals are revealing themselves to be important in the treatment and prevention of many cancers.
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